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-synuclein, that's a major ingredient of Lewy bodies, in PARK 1 in 1997 and parkin in PARK 2 in 1998, that is an E3 ubiquitin ligase and triggers endoplasmic reticulum (ER) anxiety, counsel that dysfunction of the intracellular proteinase units, for example ubiquitin-proteasome technique or lysosomal procedure, which removes avoidable poisonous pro
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